Catalytic and Noncatalytic Roles of the CtIP Endonuclease in Double-Strand Break End Resection
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- 作者：Nodar Makharashvili1 ; Anthony T. Tubbs2 ; Soo-Hyun Yang1 ; Hailong Wang3 ; Olivia Barton4 ; Yi Zhou1 ; Rajashree A. Deshpande1 ; Ji-Hoon Lee1 ; Markus Lobrich4 ; Barry P. Sleckman2 ; Xiaohua Wu3 ; Tanya T. Paull1 ; tpaull@utexas.edu" class="auth_mail
- 刊名：Molecular Cell
- 出版年：19 June 2014
- 年：2014
- 卷：54
- 期：6
- 页码：1022-1033
- 全文大小：2402 K
文摘
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Human CtIP exhibits 5′ flap endonuclease activity
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Catalytic activity is dependent on phosphorylation
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Resection of “clean” breaks does not require catalytic activity
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Resection of ends with adducts requires catalytic activity