Two thiazole dyes were selected from six disperse dyes with different structures. It is feasible to achieve ecofriendly dyeing of wool with Disperse Red 153 and Disperse Blue 148. Dyeing performance of wool was investigated in supercritical CO2. The effects of different dyeing parameters on the K/S value and fixation rate were discussed. The excellent permeability, acceptable color fastness and mechanical properties were obtained.