Decorin alleviated chronic hydrocephalus via inhibiting TGF-β1/Smad/CTGF pathway after subarachnoid hemorrhage in rats
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- 作者：Hui Yana ; 1 ; Yujie Chenb ; 1 ; Lingyong Lia ; Jiaode Jianga ; Guangyong Wua ; Yuchun Zuoa ; John H. Zhangc ; Hua Fengb ; Xiaoxin Yand ; Fei Liua ; doctorlf@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Decorin ; Subarachnoid hemorrhage ; Hydrocephalus ; Transforming growth factor-β1 ; Connective tissue growth factor ; Subarachnoid fibrosis
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：1630
- 期：Complete
- 页码：241-253
- 全文大小：4703 K
文摘
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SAH induced expressions of TGF-β1 and CTGF.
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rhDecorin improved long term cognitive functional after SAH.
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rhDecorin suppressed extracellular matrix accumulation after SAH.
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rhDecorin alleviated the incidence of chronic hydrocephalus after SAH.
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rhDecorin inhibited the expressions of TGF-β1/Smad/CTGF axis after SAH.