[¹⁸F]DPA-714, [¹⁸F]PBR111 and [¹⁸F]FEDAA1106¡ªSelective radioligands for imaging TSPO 18 kDa with PET: Automated radiosynthesis on a TRACERLAb FX-FN synthesizer and quality controls

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• 作者：Bertrand Kuhnast ; ^{bertrand.kuhnast@cea.fr} ; Annelaure Damont ; Franç ; oise Hinnen ; Tony Catarina ; Sté ; phane Demphel ; Sté ; phane Le Helleix ; Christine Coulon ; Sé ; bastien Goutal ; Philippe Gervais ; Fré ; dé ; ric Dollé
• 关键词：Fluorine-18 ; TRACERlab FX-FN ; TSPO 18  ; kDa ; [18F]DPA-714 ; [18F]FEDAA1106 ; [18F]PBR111
• 刊名：Applied Radiation and Isotopes
• 出版年：2012
• 出版时间：March 2012
• 年：2012
• 卷：70
• 期：3
• 页码：489-497
• 全文大小：603 K

文摘

Imaging of TSPO 18 kDa with PET is more and more considered as a relevant biomarker of inflammation in numerous diseases. Development of new radiotracers for TSPO 18 kDa has seen acceleration in the last years and the challenge today is to make available large amounts of such a radiotracer in compliance with GMP standards for application in humans. We present in this technical note automated productions of [¹⁸F]DPA-714, [¹⁸F]PBR111 and [¹⁸F]FEDAA1106, three promising radiotracers for TSPO 18 kDa imaging, using a TRACERlab FX-FN synthesizer. This note also includes the quality control data of the validation batches for the manufacturing qualification of clinical production of [¹⁸F]DPA-714.