ParalogousSm22α (Tagln) Genes Map to Mouse Chromosomes 1 and 9: Further Evidence for a Paralogous Relationship

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• 作者：Stanier ; Philip ; Abu-Hayyeh ; Shadi ; Murdoch ; Jennifer N. ; Eddleston ; Jane ; Copp ; Andrew J.
• 刊名：Genomics
• 出版年：1998
• 出版时间：July 1, 1998
• 年：1998
• 卷：51
• 期：1
• 页码：144-147
• 全文大小：102 K

文摘

SM22α (TAGLN) is one of the earliest markers of differentiated smooth muscle, being expressed exclusively in the smooth muscle cells of adult tissues and transiently in embryonic skeletal and cardiac tissues. We have identified and mapped the mouseTaglngene and a closely related gene,Sm22α homolog (Tagln2). The chromosomal localization forTaglnwas identified by linkage analysis to distal mouse chromosome 9 betweenD9Mit154andD9Mit330,closely linked to the anchor locusD9Nds10.The localization ofTagln2was also determined and was found to map betweenFcgr2andD1Mit149on distal mouse chromosome 1. This localization is homologous to a region of human 1q21–q25 to which an EST representing humanTAGLN2was previously mapped. The two regions, distal mouse chromosome 1 and proximal mouse chromosome 9, and the human regions with conserved synteny (1q21–q25 and 11q22–qter) are believed to be paralogous, reflecting either conserved remnants of duplicated chromosomes or segments of chromosomes during vertebrate evolution.