Phytotoxic compounds from Flourensia cernua

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• 作者：Mata ; Rachel ; Bye ; Robert ; Linares ; Edelmira ; Mací ; as ; Martha ; Rivero-Cruz ; Isabel ; Pé ; rez ; Olga ; et. al.
• 关键词：Asteraceae ; Flourensia cernua ; Amaranthus hypochondriacus ; Dehydroflourensic acid ; Echinochloa crusgalli ; Sesquiterpenoids ; Butanolides ; Calmodulin ; cAMP phosphodiesterase
• 刊名：Phytochemistry
• 出版年：2003
• 出版时间：September, 2003
• 年：2003
• 卷：64
• 期：1
• 页码：285-291
• 全文大小：203 K

文摘

Bioassay-directed fractionation of a CH₂Cl₂–MeOH (1:1) extract of the aerial parts of Flourensia cernua led to the isolation of three phytotoxic compounds, namely, dehydroflourensic acid (1), flourensadiol (2) and methyl orsellinate (3). Dehydroflourensic acid is a new natural product whose structure was established by spectral means. In addition, the known flavonoid ermanin and seven hitherto unknown γ-lactones were obtained, these being tetracosan-4-olide, pentacosan-4-olide, hexacosan-4-olide, heptacosan-4-olide, octacosan-4-olide, nonacosan-4-olide, and triacontan-4-olide. Compounds 1–3 caused significant inhibition of radicle growth of Amaranthus hypochondriacus and Echinochloa crus-galli, interacted with bovine-brain calmodulin and inhibited the activation of the calmodulin-dependent enzyme cAMP phosphodiesterase.