Maternal high-fat diet in mice programs emotional behavior in adulthood

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• 作者：Daria Peleg-Raibstein ; Edlira Luca ; Christian Wolfrum
• 关键词：Mice ; High-fat diet ; Anxiety ; Conditioned fear ; Maternal nutrition
• 刊名：Behavioural Brain Research
• 出版年：2012
• 出版时间：1 August, 2012
• 年：2012
• 卷：233
• 期：2
• 页码：398-404
• 全文大小：532 K

文摘

The maternal environment has a significant role in the normal development of the fetus and may have long-term impact on brain development including critical central pathways such as the gamma-aminobutyric acid (GABA), serotonergic and the neurotrophin systems. For example, maternal malnutrition plays an important role in programming many aspects of physiology and behavior including predisposition to mental-health related disorders such as anxiety. Here we investigated the effects of maternal high-fat diet or control diet for nine weeks (prior to gestation, gestation and lactation) on the adult offspring with respect to anxiety related behaviors as well as exploration and conditioned fear response. We found that offspring born to high-fat diet mothers showed increased anxiety-like behaviors, but intact conditioned fear response and exploratory behavior. In addition, brain-derived neurotrophic factor (BDNF) was significantly increased in the dorsal hippocampus, while GABA_A alpha2 receptor subunit and 5-hydroxytryptamine 1A (5-HT1A) receptor showed increased levels in the ventral hippocampus. In summary, these findings suggest that maternal high-fat diet consumption during critical periods in the development of the fetus, might increase the risk of abnormal behaviors in adulthood related to anxiety.