The X-Linked-Intellectual-Disability-Associated Ubiquitin Ligase Mid2 Interacts with Astrin and Regulates Astrin Levels to Promote Cell Division
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- 作者：Ankur A. Gholkar1 ; Silvia Senese1 ; Yu-Chen Lo1 ; 2 ; Edmundo Vides1 ; Ely Contreras1 ; Emmanuelle Hodara1 ; Joseph Capri3 ; Julian P. Whitelegge3 ; 4 ; 5 ; Jorge Z. Torres1 ; 4 ; 5 ; torres@chem.ucla.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mid2 ; astrin ; X-linked intellectual disability ; cell division ; cytokinesis
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：12 January 2016
- 年：2016
- 卷：14
- 期：2
- 页码：180-188
- 全文大小：4223 K
文摘
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Astrin co-purifies and localizes with Mid1 and Mid2 to cytokinetic microtubules
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Mid2 ubiquitinates astrin on K409 and targets it for degradation during cytokinesis
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Mid2 depletion leads to astrin stabilization and increased cytokinetic defects
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K409A astrin accumulates at cytokinetic microtubules and leads to cytokinetic defects