MELD-based graft allocation system fails to improve liver transplantation efficacy in a single-center intent-to-treat analysis

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• 作者：Vianney Bouygues^a ; Philippe Compagnon^a ; Marianne Latournerie^b ; Edouard Bardou-Jacquet^b ; Christophe Camus^c ; Mohamed Lakehal^a ; Bernard Meunier^a ; Karim Boudjema^a ; ^{karim.boudjema@chu-rennes.fr}
• 关键词：HCC ; Hepatocellular carcinoma ; LT ; Liver transplantation ; MELD ; Model for End-Stage Liver Disease ; WL ; Waiting list ; WT ; Waiting time
• 刊名：Clinics and Research in Hepatology and Gastroenterology
• 出版年：2012
• 出版时间：October, 2012
• 年：2012
• 卷：36
• 期：5
• 页码：464-472
• 全文大小：493 K

文摘

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Summary

Background

Since March 2007, priority access to liver transplantation in France has been given to patients with the highest MELD scores.

Objective

To undertake an intent-to-treat comparison of center-based vs. MELD-based liver graft allocation.

Methods

Retrospective cohort analysis (patients listed 6th March 2007 to 5th March 2009; MELD period) with a matched historical cohort (patients listed 6th March 2005 to 5th March 2007; pre-MELD period) in a single high-volume center. Analysis was on an intent-to-treat basis, i.e. starting on the day of wait listing.

Results

Compared to pre-MELD, fewer patients with a MELD score less or equal to 14 (P = 0.002), and more patients with a MELD greater or equal to 24 (P < 0.05) were transplanted during the MELD period. For HCC candidates, median waiting time increased (121 vs. 54 days, P = 0.01), transplantation rate halved (35 % vs. 73.5 % , P < 0.001) and dropouts due to tumor progression increased (16 % vs. 0 % , P < 0.001). Moreover, postoperative course did not change significantly except for infectious complications (35 % vs. 24 % , P = 0.02); overall patient survival was 69.8 ¡À 3.1 % vs. 76 ¡À 2.9 % (P = 0.29) and overall graft survival was 77.6 ¡À 3.4 % vs. 82.8 ¡À 2.9 % (P = 0.29). Transplant failures were mainly due to deaths on the waiting list in the previous system, but to dropouts related to disease progression in the new system. Cirrhotic patient survival rate did not change (78.1 ¡À 4.4 % vs. 73.5 ¡À 4.5 % , P = 0.42), while that of HCC patients decreased (65.3 ¡À 5.3 % vs. 86.8 ¡À 4.4 % , P = 0.01). Post-transplant survival worsened significantly according to pre-transplant MELD score (P = 0.009).

Conclusion

The MELD-based graft allocation system introduced discrimination against HCC patients, whose incidence has increased dramatically, and should be reevaluated.