Histone deacetylase and acetyltransferase inhibitors modulate behavioral responses to social stress

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• 作者：Katharine E. McCann ; ^{kmccann3@gsu.edu} ; Anna M. Rosenhauer ^{arosenhauer1@student.gsu.edu} ; Genna M.F. Jones ^{gjones26@student.gsu.edu} ; Alisa Norvelle ^{anorvelle@gsu.edu} ; Dennis C. Choi ^{dchoi15@gsu.edu} ; Kim L. Huhman ^{khuhman@gsu.edu}
• 关键词：Valproic acid ; Social defeat ; Epigenetics ; Medial prefrontal cortex
• 刊名：Psychoneuroendocrinology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：75
• 期：Complete
• 页码：100-109
• 全文大小：1602 K
• 卷排序：75

文摘

Systemic valproic acid enhances defeat-induced avoidance in males and females. HDAC inhibition in medial prefrontal cortex enhance stress-induced behavior. Histone acetylation in infralimbic cortex is necessary for conditioned defeat.