Coordination of changes in expression and phosphorylation of eukaryotic elongation factor 2 (eEF2) and eEF2 kinase in hypertrophied cardiomyocytes
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- 作者：Satoshi Kameshima ; Muneyoshi Okada ; Shiro Ikeda ; Yuki Watanabe ; Hideyuki Yamawaki ; yamawaki@vmas.kitasato-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：eEF2 ; eukaryotic elongation factor 2 ; eEF2K ; eEF2 kinase ; CAM ; calmodulin ; LV ; left ventricles ; SHR ; spontaneously hypertensive rats ; WKY ; Wistar-Kyoto rats ; TAC ; transverse aortic constriction ; IVS ; interventricular septum ; LVID ; left ventricular internal diameter ; LVPW ; left ventricular posterior wall ; ISO ; isoproterenol ; FS ; fractioning shortening ; BW ; body weight ; AMP ; adenosine monophosphate ; AMPK ; AMP-activated protein kinase
- 刊名：Biochemistry and Biophysics Reports
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：7
- 期：Complete
- 页码：218-224
- 全文大小：1072 K
文摘
eEF2 kinase (eEF2K) is a unique Ca2+/calmodulin-dependent protein kinase.
eEF2K expression increased but phosphorylation decreased in cardiac hypertrophy.
eEF2 phosphorylation increased in cardiac hypertrophy.
Expression and phosphorylation state of eEF2K/eEF2 was common to hypertrophy model.
eEF2K/eEF2 signaling might affect the pathogenesis of cardiac hypertrophy.