LAT alleviates Th2/Treg imbalance in an OVA-induced allergic asthma mouse model through LAT-PLC-γ1 interaction

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• 作者：Xi Chen ; Xiao-ming Li ; Wen Gu ; Di Wang ; Yi Chen ; Xue-jun Guo ; ^{guoxj1964@126.com}
• 关键词：LAT ; PLC-γ1 ; Asthma ; Th2 cells ; Treg cells
• 刊名：International Immunopharmacology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：44
• 期：Complete
• 页码：9-15
• 全文大小：1125 K
• 卷排序：44

文摘

Th2/Treg imbalance is disrupted in OVA-induced allergic asthma Site-specific delivery of LAT DNA rectified Th2/Treg imbalance in OVA-induced allergic asthma. LAT-PLC-γ1 interaction contributes to rectification of Th2/Treg imbalance partly via Raf-MEK-ERK and PI3K-AKT-CREB pathways.