The role of ultrasound-guided transcutaneous tru-cut biopsy in diagnosing untreated and recurrent laryngo-hypopharyngeal masses

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• 作者：Elvio De Fiori^a ; ^{elvio.de-fiori@ieo.it" class="auth_mail" title="E-mail the corresponding author} ; Giorgio Conte^b ; ^{giorgioconte.unimed@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; ^{giorgio.conte@ieo.it" class="auth_mail" title="E-mail the corresponding author} ; Mohssen Ansarin^c ; ^{mohssen.ansarin@ieo.it" class="auth_mail" title="E-mail the corresponding author} ; Luigi De Benedetto^c ; ^{luigi.debenedetto@ieo.it" class="auth_mail" title="E-mail the corresponding author} ; Luke Bonello^b ; ^{luke_bonello@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Daniela Alterio^d ; ^{daniela.alterio@ieo.it" class="auth_mail" title="E-mail the corresponding author} ; Fausto Maffini^e ; ^{fausto.maffini@ieo.it" class="auth_mail" title="E-mail the corresponding author} ; Massimo Bellomi^a ; ^b ; ^{massimo.bellomi@ieo.it" class="auth_mail" title="E-mail the corresponding author} ; Lorenzo Preda^a ; ^{lorenzo.preda@ieo.it" class="auth_mail" title="E-mail the corresponding author}
• 关键词：USGTCB ; Ultrasound-Guided Transcutaneous Tru-Cut biopsy ; FNAC ; fine needle aspiration cytology ; SCC ; squamous cell carcinoma
• 刊名：European Journal of Radiology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：85
• 期：1
• 页码：158-163
• 全文大小：1004 K

文摘

To evaluate the diagnostic performance of Ultrasound-guided Transcutaneous Tru-Cut biopsy (USGTCB) of laryngo-hypopharyngeal masses suspicious for malignancy. Furthermore we investigated whether USGTCB is accurate for both untreated masses and suspected recurrences.

Materials and methods

From August 2004 to July 2014 we prospectively enrolled 66 patients for a total of 68 USGTCBs: 38 USGTCB were performed for a suspicious untreated mass and in 30 for a suspected recurrence. We calculated the sensitivity, specificity, positive predictive value and negative predictive value for all procedures and separately for untreated masses and suspected recurrences.

Results

USGTCB diagnosed 57 malignancies (51 squamous cell carcinomas, 6 other tumors) and 11 benign lesions. There were no false positives reported, whereas five false negatives were observed: two in patients with an untreated mass, three in patients with a suspected recurrence. Overall, the sensitivity of the technique was 91.9% (95% confidence interval [CI]: 82.2–97.3%); the specificity was 100% (95% CI: 54.1–100%); positive and negative predictive values were 100% (95% CI: 93.7–100%) and 54.5% (95% CI: 23.5–83.1%) respectively, with similar performances in untreated masses and suspected recurrences of SCC.

Conclusion

USGTCB is an effective procedure for the histological diagnosis of laryngo-hypopharyngeal masses suspicious for malignancy in patients showing contraindications to biopsy via microlaryngoscopy under general, with similar performances for untreated masses and suspected recurrences.