Prophylactic and therapeutic intranasal administration with an immunomodulator, Hiltonol^® (Poly IC:LC), in a lethal SARS-CoV-infected BALB/c mouse model

详细信息    查看全文

• 作者：Yohichi Kumaki^a ; ^{yohichi.kumaki@usu.edu} ; Andres M. Salazar^b ; Miles K. Wandersee^a ; Dale L. Barnard^a
• 关键词：BALB/c mouse ; Hiltonol® ; SARS-CoV ; MERS-CoV
• 刊名：Antiviral Research
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：139
• 期：Complete
• 页码：1-12
• 全文大小：1990 K
• 卷排序：139

文摘

We evaluated the use of Hiltonol® for treating lethal SARS-CoV-infected BALB/c mice. Hiltonol® treatment leads to prophylactic and therapeutic effects. These properties might be therapeutically advantageous.