Evaluation of cellular uptake, cytotoxicity and cellular ultrastructural effects of heteroleptic oxidovanadium(IV) complexes of salicylaldimines and polypyridyl ligands

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• 作者：Gonzalo Scalese^a ; Isabel Correia^b ; Julio Bení ; tez^a ; Santiago Rostá ; n^a ; Fernanda Marques^c ; Filipa Mendes^c ; Antó ; nio Pedro Matos^d ; Joã ; o Costa Pessoa^b ; ^{joao.pessoa@ist.utl.pt} ; Dinorah Gambino^a ; ^{dgambino@fq.edu.uy}
• 关键词：Oxidovanadium(IV) complexes ; Salicylaldimines ; Polypyridyl ligands ; Anticancer drugs ; Cellular uptake ; Cellular ultrastructural effects
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：166
• 期：Complete
• 页码：162-172
• 全文大小：1216 K
• 卷排序：166

文摘

A set of eight novel mixed-ligand vanadium complexes are synthesized and characterized. The V complexes depict no or very low DNA-cleavage activity. Subcellular distribution indicates that compounds target different cellular components. Compounds produce membrane alterations, nuclear atypia and mitochondria densification.