Triptolide reduces expression of hTERT by decreasing its transcription level.
Triptolide reduces promoter activity and stability of hTERT.
Triptolide down-regulates expression of Sp1.
Special Sp1 shRNAs inhibit transcription and protein expression of hTERT.
Triptolide and Sp1 shRNA2 induce cell proliferation inhibition and apoptosis.