Chlorogenic acid suppresses monocrotaline-induced sinusoidal obstruction syndrome: The potential contribution of NFκB, Egr1, Nrf2, MAPKs and PI3K signals
详细信息 查看全文
- 作者：Zhiyong Zhenga ; Liang Shia ; Yuchen Shengb ; Jiaqi Zhanga ; Bin Lua ; Lili Jia ; lichenyue1307@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ALT/AST ; alanine/aspartate aminotransferase ; CGA ; chlorogenic acid ; Egr1 ; early growth response1 ; GCL ; glutamate cysteine ligase ; H&E ; hematoxylin-eosin ; HSCT ; hematopoietic stem cell transplantation ; HVOD ; hepatic veno-occlusive obstruction ; IκB ; inhibitor of kappa B ; IL-1β ; interleukin-1β ; LPO ; lipid peroxidation ; MAPKs ; mitogen-activated protein kinases ; MCT ; monocrotaline ; MDA ; malondialdehyde ; MMP-9 ; metalloproteinase-9 ; MOF ; multiorgan failure ; MPO ; myeloperoxidase ; MyD88 ; myeloid differen
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：46
- 期：Complete
- 页码：80-89
- 全文大小：3728 K
文摘
- •
CGA attenuated MCT-induced SOS in rats.
- •
CGA attenuated MCT-induced hepatic inflammation and oxidative injury.
- •
CGA inhibited MCT-induced transcriptional activation of NFκB and Egr1.
- •
CGA enhanced Nrf2 transcriptional activation.
- •
CGA abrogated MCT-induced activation of MAPKs and PI3K signaling pathways.