Cognitive deficits triggered by early life stress: The role of histone deacetylase 1
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- 作者：Samantha M. Adlera ; Claudia Schmaussa ; b ; cs581@cumc.columbia.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Working memory ; Attention set-shifting ; HDAC1 activity ; Bdnf promotor ; Egr2 promotor ; Gene expression
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：94
- 期：Complete
- 页码：1-9
- 全文大小：823 K
文摘
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Early life stress triggers persistent executive cognitive deficits
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Early life stress leads to reduced histone deacetylase 1 (HDAC1) levels at promotors of certain plasticity-associated genes
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The genes affected by reduced promotor-associated HDAC1 levels are determined by the genetic background
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Reduced HDAC1 activity predisposes to enhanced gene expression in response to cognitive task exposure
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Enhanced expression of the affected genes negatively influences cognitive task performance