Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy
文摘
12 novel multitarget directed ligands for Alzheimer's disease. The in vitro enzymatic and hepatotoxic activities were evaluated. The primary structure–activity relationships were discussed. Compound 2h is non-hepatotoxic, and selective hAChE inhibitor.