Reduced-Intensity Conditioning Combined with 188Rhenium Radioimmunotherapy before Allogeneic Hematopoietic Stem Cell Transplantation in Elderly Patients with Acute Myeloid Leukemia: The Role of In聽Vivo T Cell Depletion
详细信息 查看全文
- 作者：Sebastian Schneider1 ; Annette Strumpf2 ; Johannes Schetelig1 ; Gerd Wunderlich2 ; Gerhard Ehninger1 ; Jö ; rg Kotzerke2 ; Martin Bornhä ; user1 ; 3 ; martin.bornhaeuser@uniklinikum-dresden.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acute myeloid leukemia ; Stem cell transplantation ; Reduced-intensity conditioning ; Alemtuzumab ; Re-188 radioimmunotherapy
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：21
- 期：10
- 页码：1754-1760
- 全文大小：713 K
文摘
- •
We combined reduced-intensity conditioning and 188rhenium anti-CD66 radioimmunotherapy in a prospective phase II trial.
- •
Associated with limited extramedullary toxicity in 58 patients with high-risk acute myeloid leukemia/myelodysplastic syndrome.
- •
Reduction of Campath-1H from 75 to 50 mg did not improve overall outcome.
- •
Further optimization of the current approach is needed.