Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors
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- 作者：Joshua Levitz1 ; 2 ; 5 ; Chris Habrian1 ; 2 ; Shashank Bharill1 ; Zhu Fu1 ; Reza Vafabakhsh1 ; Ehud Y. Isacoff1 ; 2 ; 3 ; 4 ; 6 ; ehud@berkeley.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Neuron
- 出版年：2016
- 出版时间：5 October 2016
- 年：2016
- 卷：92
- 期：1
- 页码：143-159
- 全文大小：4850 K
文摘
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mGluRs assemble into strict homo- or heterodimers, primarily via inter-LBD interactions
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LBD interfaces modulate conformational dynamics and activation
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Homomeric subunit interaction between mGluR2 subunits yields activation cooperativity
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Spontaneous dynamics yield asymmetric cooperativity in mGluR2/3 heterodimers