Activation of cathepsin L contributes to the irreversible depolarization induced by oxygen and glucose deprivation in rat hippocampal CA1 neurons

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• 作者：Shogo Kikuta^a ; ^b ; ^{kikuta_shougo@med.kurume-u.ac.jp} ; Yoshinaka Murai^a ; ^{ymurai@med.kurume-u.ac.jp} ; Eiichiro Tanaka^a
• 关键词：Hippocampus ; CA1 neuron ; Ischemia ; Cathepsin L
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：636
• 期：Complete
• 页码：120-126
• 全文大小：1151 K
• 卷排序：636

文摘

Oxygen and glucose deprivation (OGD) induced dysfunction of the neuronal membrane. Cathepsin L inhibitors protected the membrane dysfunction after 30 min post-OGD. Activation of cathepsin L may induce the membrane dysfunction after OGD.