Calcium homeostasis in mitochondrion-mediated apoptosis of chick embryo cecal epithelial cells induced by Eimeria tenella infection
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- 作者：Xiao-zhen Cui ; Ming-xue Zheng ; zhengmingxue288@163.com" class="auth_mail" title="E-mail the corresponding author ; Yan Zhang ; Rui-li Liu ; Sha-sha Yang ; Shan Li ; Zhi-yong Xu ; Rui Bai ; Qiang-hua Lv ; Wen-long Zhao
- 关键词：Eimeria tenella ; Mitochondrial ; Apoptosis ; Cytosolic calcium ; Cytochrome c
- 刊名：Research in Veterinary Science
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：104
- 期：Complete
- 页码：166-173
- 全文大小：2723 K
文摘
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We examined the role of Ca2 + in mitochondrial apoptosis during Eimeria tenella infection.
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Cytosolic [Ca2 +] and apoptosis increased in chick cecal epithelial cells infected by Eimeria tenella.
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The increases were abolished by blocking extracellular Ca2 + influx and ER Ca2 + channel release.
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Restoring Ca2 + homeostasis can suppress apoptosis induced by Eimeria tenella infection.