Intercellular Coupling of the Cell Cycle and Circadian Clock in Adult Stem Cell Culture

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• 作者：Toru Matsu-ura¹ ; Andrey Dovzhenok² ; Eitaro Aihara¹ ; Jill Rood³ ; Hung Le¹ ; Yan Ren⁴ ; Andrew E. Rosselot¹ ; Tongli Zhang¹ ; Choogon Lee⁵ ; Karl Obrietan⁶ ; Marshall H. Montrose¹ ; Sookkyung Lim² ; Sean R. Moore³ ; ⁸ ; ^{sean.moore@virginia.edu} ; Christian I. Hong¹ ; ⁷ ; ⁹ ; ^{christian.hong@uc.edu}
• 关键词：circadian rhythm ; cell cycle ; coupled oscillators ; intestinal crypt ; intestinal stem cell ; progenitor cell ; Paneth cell ; WNT signaling ; intercellular coupling
• 刊名：Molecular Cell
• 出版年：2016
• 出版时间：1 December 2016
• 年：2016
• 卷：64
• 期：5
• 页码：900-912
• 全文大小：4002 K
• 卷排序：64

文摘

The circadian clock gates cell-cycle progression in the intestinal epithelium The circadian clock is less robust in intestinal stem and progenitor cells WNT secreted from Paneth cells couples the circadian clock and cell cycle