Pallidal stimulation in dystonia affects cortical but not spinal inhibitory mechanisms
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- 作者：Vá ; clav Bočeka ; 1 ; Ivana &Scaron ; tětká ; řová ; a ; ivana.stetkarova@fnkv.cz" class="auth_mail" title="E-mail the corresponding author ; Anna Fečí ; ková ; b ; 1 ; Vá ; clav Čejkab ; Du&scaron ; an Urgo&scaron ; í ; kc ; Robert Jechb
- 关键词：Deep brain stimulation ; Cortical inhibition ; Spinal inhibition ; Globus pallidus ; Dystonia ; Cutaneous silent period ; Cortical silent period ; H-reflex
- 刊名：Journal of the Neurological Sciences
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：369
- 期：Complete
- 页码：19-26
- 全文大小：671 K
文摘
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The cortical not the cutaneous silent period is affected in dystonia of various etiology treated with GPi DBS.
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The cortical silent period (CoSP) in dystonia is longer with GPi DBS suggesting increase of cortical inhibitory effects.
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The GPi DBS-related prolongation of the CoSP in dystonia reached similar values as in healthy group suggesting normalization.
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The inhibitory effects of GPi DBS varied with phenotype implying several pathophysiological mechanisms in dystonia.