Signalling by the ¦Âc family of cytokines
详细信息 查看全文
- 作者：Timothy R. Hercus ; Urmi Dhagat ; Winnie L.T. Kan ; Sophie E. Broughton ; Tracy L. Nero ; Michelle Perugini ; Jarrod J. S ; ow ; Richard J. D¡¯Andrea ; Paul G. Ekert ; Timothy Hughes ; Michael W. Parker ; Angel F. Lopez
- 关键词：¦Â Common receptor ; Cytokines ; Inflammation ; Leukaemia ; Signalling
- 刊名：Cytokine and Growth Factor Reviews
- 出版年：2013
- 出版时间：June, 2013
- 年：2013
- 卷：24
- 期：3
- 页码：189-201
- 全文大小：1752 K
文摘
The GM-CSF, IL-3 and IL-5 family of cytokines, also known as the ¦Âc family due to their receptors sharing the signalling subunit ¦Âc, regulates multiple biological processes such as native and adaptive immunity, inflammation, normal and malignant hemopoieis, and autoimmunity. Australian scientists played a major role in the discovery and biological characterisation of the ¦Âc cytokines and their recent work is revealing unique features of cytokine receptor assembly and signalling. Furthermore, specific antibodies have been generated to modulate their function. Characterisation of the structural and dynamic requirements for the activation of the ¦Âc receptor family and the molecular definition of downstream signalling pathways are providing new insights into cytokine receptor signalling as well as new therapeutic opportunities.