Synthesis of polycarbonate urethane elastomers and effects of the chemical structures on their thermal, mechanical and biocompatibility properties

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• 作者：Rong Zhu^a ; ^b ; Yiyu Wang^a ; ^b ; Zongrui Zhang^a ; ^b ; Daiwei Ma^a ; ^b ; Xinyu Wang^a ; ^b ; ^{wangxinyu@whut.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Bioengineering ; Developmental biology
• 刊名：Heliyon
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：2
• 期：6
• 全文大小：1141 K

文摘

In this study, to obtain biomedical polyurethane elastomers with good mechanical properties and biocompatibility, a series of polycarbonate urethanes were synthesized via a two-step solution of polymerization method using the poly(1,6-hexanediol)carbonate diols (PCDL) as the soft segment, 4,4′-methylenebis(cyclohexyl isocyanate) (H₁₂MDI), 1,6-hexamethylene diisocyanate (HDI) and 1,4-butanediol (BDO) as the hard segment with dibutyltin dilaurate as the catalyst. In this article, we illustrated the physical behaviors were obviously influenced by synthetic routes. And their chemical and physical structures were investigated by gel permeation chromatograph (GPC), differential scanning calorimeter (DSC), fourier transform infrared spectrography (FT-IR) and mechanical properties tests. The surface wettability were studied by contact angle measurement (CA). As a kind of short-term implant biomaterial, the results of the hemolysis and platelet adhesive tests were recorded by spectrophotometer and scanning electron microscopy (SEM), indicating the materials have a great potential for developments and applications in biomedical field.