Photocrosslinkable biodegradable elastomers based on cinnamate-functionalized polyesters

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• 作者：Congcong Zhu^a ; Stephen R. Kustra^b ; Christopher J. Bettinger^a ; ^b ; ^c ; ^{cbetting@andrew.cmu.edu}
• 关键词：Polymer ; Biodegradable ; Cinnamate ; Elastomers ; Photocrosslink
• 刊名：Acta Biomaterialia
• 出版年：2013
• 出版时间：July, 2013
• 年：2013
• 卷：9
• 期：7
• 页码：7362-7370
• 全文大小：1654 K

文摘

Synthetic biodegradable elastomers are an emerging class of materials that play a critical role in supporting innovations in bioabsorbable medical implants. This paper describes the synthesis and characterization of poly(glycerol-co-sebacate)-cinnamate (PGS-CinA), a biodegradable elastomer based on hyperbranched polyesters derivatized with pendant cinnamate groups. PGS-CinA can be prepared via photodimerization in the absence of photoinitiators using monomers that are found in common foods. The resulting network exhibits a Young¡¯s modulus of 50.5-152.1 kPa and a projected in vitro degradation half-life time between 90 and 140 days. PGS-CinA elastomers are intrinsically cell-adherent and support rapid proliferation of fibroblasts. Spreading and proliferation of fibroblasts are loosely governed by the substrate stiffness within the range of Young¡¯s moduli in PGS-CinA networks that were prepared. The thermo-mechanical properties, biodegradability and intrinsic support of cell attachment and proliferation suggest that PGS-CinA networks are broadly applicable for use in next generation bioabsorable materials including temporary medical devices and scaffolds for soft tissue engineering.