A novel algorithm to predict the QT interval during intrinsic atrioventricular conduction from an electrocardiogram obtained during ventricular pacing

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• 作者：Roy Sriwattanakomen ; MD ; ^{rsriwat1@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Kenneth J. Mukamal ; MD ; MPH ; Alexei Shvilkin ; MD ; PhD
• 关键词：Prediction ; QT interval ; TpeakTend ; JTpeak ; Repolarization remodeling ; Ventricular pacing ; Cardiac memory
• 刊名：Heart Rhythm
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：13
• 期：10
• 页码：2076-2082
• 全文大小：1302 K

文摘

QT interval prolongation is a major arrhythmia risk factor. Standard QT interval limits are defined for preserved intrinsic atrioventricular and interventricular conduction. However, ventricular pacing (VP) prolongs the QRS duration, induces electrical remodeling, and therefore obscures the intrinsic QT interval. No consensus exists on QT interval monitoring during VP.

Objective

The aim of this study was to develop an algorithm to predict the QT interval during intrinsic conduction (IC) from the VP electrocardiogram.

Methods

We measured electrocardiographic intervals QRS, QT, QT_peak, JT_peak, and T_peakT_end in 38 participants with cardiac devices and preserved atrioventricular and interventricular conduction. We performed paired measurements in AAI (IC) and DDD (VP) pacing modes at equal heart rates at baseline and after 1 week of VP. We fit linear mixed models to predict IC QT intervals from VP intervals and compared their fit with other proposed methods of IC QT interval estimation.

Results

After 1 week of VP, the IC QT interval prolonged while the VP QT interval shortened from their respective baseline values. VP QT interval shortening was due to T_peakT_end interval shortening. JT_peak and QT_peak intervals prolonged in both pacing modes at 1 week. A formula using VP QT_peak interval and heart rate closely predicted the IC QT interval (r = 0.94), outperforming other methods, including subtraction of “excess” QRS duration from the actual QT interval (r = 0.64) and subtraction of fixed values from heart rate–corrected QT interval (r = 0.58 and r = 0.69). Validation in 2000 bootstrapped data sets confirmed the model’s performance (r = 0.93) compared to others (r = 0.43–0.58).

Conclusion

In patients with VP, a formula using the QT_peak interval accurately predicts the intrinsic QT interval.