Bismuth (III) oxide/glassy carbon sensor for sensing of antidepressant drug escitalopram in micellar media

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• 作者：Rajeev Jain ; Dhanjai ; Sanjay Sharma
• 关键词：Bismuth (III) oxide/glassy carbon electrode (Bi2O3/GCE) ; Voltammetry ; Electrochemical sensor ; Micellar media ; Escitalopram
• 刊名：Colloids and Surfaces A: Physicochemical and Engineering Aspects
• 出版年：2013
• 出版时间：5 September, 2013
• 年：2013
• 卷：436
• 期：Complete
• 页码：178-184
• 全文大小：1896 K

文摘

A sensitive escitalopram sensor has been developed using a bismuth (III) oxide (Bi₂O₃) nano-particles-modified-glassy carbon electrode (GCE). The bismuth (III) oxide was mechanically deposited on to the surface of GCE in N,N-dimethylformamide solution and was characterized by scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The sensor showed an excellent electro-catalytic activity toward oxidation of escitalopram. Micellar media was also used for solubilizing the escitalopram and it shows enhancement effect. The oxidative current increased linearly with increasing concentration of escitalopram at Bi₂O₃/GCE from 150 ¦Ìg/mL to 400 ¦Ìg/mL and detection limit was calculated to be 53.67 ¦Ìg/mL. The fabricated sensor can be used for the determination of escitalopram in pharmaceutical formulation.