Determination of deferasirox in human plasma by short-end injection and sweeping with a field-amplified sample stacking and micellar electrokinetic chromatography
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- 作者：Hung-Ju Lina ; Kun-Pin Hsieha ; Shyh-Shin Chioub ; c ; Hwang-Shang Koua ; kouhs@kmu.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Shou-Mei Wua ; d ; shmewu@kmu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：BGE ; background electrolyte ; CE ; capillary electrophoresis ; DFX ; deferasirox ; EOF ; electroosmotic flow ; FASS ; field-amplified sample stacking ; HPLC ; high-performance liquid chromatography ; LOD ; limit of detection ; LOQ ; limit of quantitation ; MEKC ; micellar electrokinetic chromatography ; MS ; mass spectrometry ; SDS ; sodium dodecyl sulfate ; SI ; short-end injection ; UGT1A1 ; UDP-glucuronosyltransferase 1A subfamily ; UV ; ultraviolet
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：30 November 2016
- 年：2016
- 卷：131
- 期：Complete
- 页码：497-502
- 全文大小：999 K
文摘
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Short-end injection combined with sweeping-FASS MEKC was a new CE method for determination of deferasirox in plasma.
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The established CE method was applied for determination of deferasirox in five clinical β-thalassemia patients.
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Separation time of deferasirox by the CE method was within 3.5 min.