Antioxidative stress effect of epicatechin and catechin induced by Aβ25-35 in rats and use of the electrostatic potential and the Fukui function as a tool to elucidate specific sites of interaction
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- 作者：Trinidad Cruz-Gonzá ; leza ; Estephania Cortez-Torresb ; Francisca Perez-Severianoc ; Blanca Espinosad ; Jorge Guevarae ; Aaró ; n Perez-Benitezf ; Francisco J. Melendezg ; Alfonso Dí ; azh ; alfonso.diaz@correo.buap.mx" class="auth_mail" title="E-mail the corresponding author ; Ramsé ; s E. Ramí ; reza ; ramses.ramirez@correo.buap.mx" class="auth_mail" title="E-mail the corresponding author
- 关键词：Amyloid- β25&ndash ; 35 ; Flavonoid compounds ; Oxidative stress ; Hippocampus ; Astrocytes ; Electrostatic potential
- 刊名：Neuropeptides
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：59
- 期：Complete
- 页码：89-95
- 全文大小：991 K
文摘
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The Aβ25–35 activates microglia and free radicals that cause neuronal death.
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Epicatechin and catechin decrease oxidative stress and neuroinflammation.
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Epicatechin and catechin reduce the toxicity of Aβ25–35 in the hippocampus.
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The methionine and lysine of Aβ25–35 represented higher electron densities.
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The flavonoids blocking the interaction of electrophilic sites of Aβ25–35