Global proteomic effect of S3I201 in U87 glioma cells was examined.
A total of 136 differentially expressed proteins were identified with diverse functions.
Cellular metabolism, apoptosis, cytoskeletal regulation and cell redox homeostasis were significantly altered.
Up-regulations of TPI1, PGAM1, PFKC, HK1, AIFM, HSP90β and proteins belong to classical complement pathway were observed.
Down-regulation of several ribosomal proteins including PCNA was observed.