Molecular mechanisms of cardiac electromechanical remodeling during Chagas disease: Role of TNF and TGF-β

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• 作者：Jader Santos Cruz ; PhD^a ; Fabiana Simã ; o Machado ; PhD^a ; Catherine Ropert ; PhD^a ; Danilo Roman-Campos ; PhD^b ; ^{drcampos@unifesp.br} ; ^{drcbio@gmail.com}
• 关键词：Chagas disease ; Cardiac electrophysiology ; Action potential ; Cytokine ; Tumor necrosis factor ; Trypanosoma cruzi
• 刊名：Trends in Cardiovascular Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：27
• 期：2
• 页码：81-91
• 全文大小：558 K
• 卷排序：27

文摘

Chagas disease is caused by the trypanosomatid Trypanosoma cruzi, which chronically causes heart problems in up to 30% of infected patients. Chagas disease was initially restricted to Latin America. However, due to migratory events, this disease may become a serious worldwide health problem. During Chagas disease, many patients die of cardiac arrhythmia despite the apparent benefits of anti-arrhythmic therapy (e.g., amiodarone). Here, we assimilate the cardiac form of Chagas disease to an inflammatory cardiac disease. Evidence from the literature, mostly provided using experimental models, supports this view and argues in favor of new strategies for treating cardiac arrhythmias in Chagas disease by modulating cytokine production and/or action. But the complex nature of myocardial inflammation underlies the need to better understand the molecular mechanisms of the inflammatory response during Chagas disease. Here, particular attention has been paid to tumor necrosis factor alpha (TNF) and transforming growth factor beta (TGF-β) although other cytokines may be involved in the chagasic cardiomyopathy.