Mathematical model for transport of DNA plasmids from the external medium up to the nucleus by electroporation

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• 作者：M. Leguè ; be^a ; M.G. Notarangelo^b ; M. Twarogowska^c ; R. Natalini^b ; C. Poignard ; ^d ; ^{clair.poignard@inria.fr}
• 关键词：Mathematical biology ; Intracellular transport ; Microtubules ; Plasmids transport ; Finite difference method in irregular domains
• 刊名：Mathematical Biosciences
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：285
• 期：Complete
• 页码：1-13
• 全文大小：1739 K
• 卷排序：285

文摘

Multiscale model of cell transfection by mean of electroporation, from the outer cellular medium up to the nucleus. Efficient numerical methods in 2D and 3D, that makes it possible forthcoming in silico optimization of cell transfection. Qualitative validation with the experimental observations found in the literature.