A kind of rd1 mouse in C57BL/6J mice from crossing with a mutated Kunming mouse

详细信息    查看全文

• 作者：Weiming Yan^a ; ¹ ; Lu Yao^a ; ¹ ; Wei Liu^b ; ¹ ; Kai Sun^a ; ZuoMing Zhang^a ; ^{zhangzm@fmmu.edu.cn} ; Lei Zhang^a ; ^{sanshizhanglei@126.com}
• 关键词：KM ; Kunming ; RP ; retinitis pigmentosa ; qRT-PCR ; quantitative real time polymerase chain reaction ; ERG ; electroretinogram ; ONL ; outer nuclear layer ; cGMP ; cyclic guanosine monophosphate ; PDE ; phosphodiesterase ; WT ; wild type
• 刊名：Gene
• 出版年：2017
• 出版时间：5 April 2017
• 年：2017
• 卷：607
• 期：Complete
• 页码：9-15
• 全文大小：1033 K
• 卷排序：607

文摘

KM/rd and B6/rd mice display autosomal recessive hereditary retinal degeneration. The mutation point of KM/rd and B6/rd is the nonsense mutation that converts the codon 347 (TAC) to a stop codon (TAA). KM/rd and B6/rd are proved to be rd1, indicating that they can be used as an mouse mode1 of retinitis pigmentosa (RP). KM/rd and B6/rd are the first RP mouse model in China from an outbreed strain, which is more similar to human reproduction.