Structural elucidation and protective role of a polysaccharide from Sargassum fusiforme on ameliorating learning and memory deficiencies in mice
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- 作者：Pei Hua ; b ; 1 ; Zhixiong Lia ; 1 ; Mingcang Chena ; Zhaolin Suna ; Yun Lingc ; Jian Jiangb ; jianjiangsg@126.com" class="auth_mail" title="E-mail the corresponding author ; Chenggang Huanga ; cghsimm@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer's disease ; SFPS65 ; Sargassum fusiforme polysaccharide 65 ; LC&ndash ; ESI-Q-TOF-MS ; high-performance liquid chromatography coupled with electrospray ionization quadruple time-of-flight tandem mass spectrometry ; HPGPC ; high-performance gel permeation chromatography ; IR ; infrared spectrum ; NMR ; nuclear magnetic resonance ; CMC-Na ; sodium carboxymethylcellulose
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：30 March 2016
- 年：2016
- 卷：139
- 期：Complete
- 页码：150-158
- 全文大小：2108 K
文摘
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A new fucoidan was isolated from Sargassum fusiforme.
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The predicted structure of fucoidan was elucidated by chemical and spectral methods.
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The fucoidan exhibited a good effect on improving cognitive dysfunction of the mice.
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The fucoidan was the main medicinal ingredients on treatment of Alzheimer's disease.