Simultaneous quantitation of nine hydroxy-androgens and their conjugates in human serum by stable isotope dilution liquid chromatography electrospray ionization tandem mass spectrometry

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• 作者：Tianzhu Zang^a ; Daniel Tamae^a ; Clementina Mesaros^a ; ^b ; Qingqing Wang^b ; Meng Huang^a ; Ian A. Blair^a ; ^b ; Trevor M. Penning^a ; ^b ; ^{penning@upenn.edu}
• 关键词：Castration resistant prostate cancer ; Androgen conjugates ; Androgen diols ; Enzymatic synthesis ; Picolinic acid derivatization ; LC-ESI-MS/MS
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：165
• 期：part_PB
• 页码：342-355
• 全文大小：2787 K
• 卷排序：165

文摘

Stereoselective enzymatic synthesis of stable isotope labeled androstanediols. Simultaneous quantitation of nine hydroxy-androgens in human serum by LC–MS/MS. Quantitation of 5-androstenediol and its conjugates in human serum using LC–MS/MS. Quantitation of 3α- and 3β-androstanediol and their conjugates in human serum using LC–MS/MS.