The beneficial role of simultaneous splenectomy after extended hepatectomy: experimental study in pigs

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• 作者：Antonios Athanasiou ; MD ; PhD^a ; ^{antwnis_athanasiou@hotmail.com} ; Apostolos Papalois ; PhD^b ; Michael Kontos ; MD ; PhD^a ; John Griniatsos ; MD ; PhD^a ; Dimitrios Liakopoulos ; MD^a ; Eleftherios Spartalis ; MD ; PhD^a ; George Agrogiannis ; MD ; PhD^c ; Theodoros Liakakos ; MD ; PhD^a ; Emmanouil Pikoulis ; MD ; PhD^a
• 关键词：Hepatectomy ; Animal model ; Portal vein ; Small-for-size syndrome ; Liver
• 刊名：Journal of Surgical Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：208
• 期：Complete
• 页码：121-131
• 全文大小：3557 K
• 卷排序：208

文摘

The role of hepatic hemodynamic modulation in the development of “small-for-size” syndrome (SFSS) after extended hepatectomy (EH) or living-donor liver transplantation is still controversial. We have designed an experimental study to investigate the effect of hemodynamic parameters of the liver circulation on the development of SFSS after EH in a porcine model.MethodsEighteen pigs were randomly divided into two groups: group A has received EH (75%-80%) without splenectomy, and group B with EH and simultaneous splenectomy was carried out. Portal hemodynamics, liver function tests, histologic findings, injury and survival rates were compared between groups A and B.ResultsThe 7-d survival rate in the splenectomy group was significantly improved compared with group A (88.9% versus 44.4%, P < 0.05). Portal vein pressure, portal vein flow, and liver function tests in the splenectomy group were significantly lower than in group A immediately after splenectomy and postoperatively until the day of sacrifice. Histologic findings in group A clearly illustrate severe inflammation, bridging necrosis, ischemic cholangitis, and severe congestion, while in group B there were less serious histologic changes.ConclusionsOur experimental study indicates that perioperative portal modulation can successfully prevent the manifestation of SFSS after EH. Therefore, by focusing on “flow” rather than on “size,” researchers may understand better the pathophysiology of this syndrome.