Glio-vascular modifications caused by Aquaporin-4 deletion in the mouse retina
详细信息 查看全文
- 作者：Grazia Paola Nicchiaa ; b ; 1 ; graziapaola.nicchia@uniba.it" class="auth_mail" title="E-mail the corresponding author ; Francesco Pisania ; 1 ; Laura Simonea ; c ; Antonio Cibellia ; Maria Grazia Molaa ; Massimo Dal Monted ; Antonio Frigerib ; e ; Paola Bagnolid ; Maria Sveltoa ; f ; g
- 关键词：Aquaporin-4 ; Retina ; Neuromyelitis optica ; Gliovascular biology ; Blood-retinal barrier ; Intraretinal vasculature ; Astrocytes ; Mü ; ller cells
- 刊名：Experimental Eye Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：146
- 期：Complete
- 页码：259-268
- 全文大小：3134 K
文摘
- class="listitem" id="list_ulist0010">
- class="label">•
AQP4 is important in maintaining the BRB integrity at the deep plexus.
- class="label">•
AQP4 deletion causes an inflammatory response and a reactive phenotype restricted to astrocytes at the superficial plexus.
- class="label">•
The astrocyte reaction is strictly linked to gliovascular crosstalk.
- class="label">•
Differential regulatory elements are involved in activation of astrocytes and Muller cells.