Protection of mice against the highly pathogenic VVIHD-J by DNA and fowlpox recombinant vaccines, administered by electroporation and intranasal routes, correlates with serum neutralizing activity
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- 作者：Massimiliano Bissaa ; 1 ; 2 ; massimiliano.bissa@nih.gov" class="auth_mail" title="E-mail the corresponding author ; Elena Quaglinob ; 2 ; elena.quaglino@unito.it" class="auth_mail" title="E-mail the corresponding author ; Carlo Zanottoc ; carlo.zanotto@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Elena Illianoa ; elena.illiano@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Valeria Rolihb ; valeria.rolih@unito.it" class="auth_mail" title="E-mail the corresponding author ; Sole Pacchionia ; sol83@libero.it" class="auth_mail" title="E-mail the corresponding author ; Federica Cavallob ; federica.cavallo@unito.it" class="auth_mail" title="E-mail the corresponding author ; Carlo De Giuli Morghenc ; d ; 3 ; carlo.degiulimorghen@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Antonia Radaellia ; e ; 3 ; antonia.radaelli@unimi.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Recombinant vaccines ; Fowlpox virus ; Prime/boost ; OPXV vaccine ; L1R ; A27L ; A33R ; B5R VV genes ; Intranasal mucosal vaccination
- 刊名：Antiviral Research
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：134
- 期：Complete
- 页码：182-191
- 全文大小：982 K
文摘
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Vaccination with DNA/FP recombinants protects mice against the pathogenic VVIHD-J.
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The specific humoral response correlates with protection.
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Only protected mice show specific VVIHD-J neutralizing antibodies.
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After i.n. FP vaccination, mice are protected against higher VVIHD-J challenges.
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The role of cellular immune response appears to be ascribed to A27 protein.