Polylysine–porphycene conjugates as efficient photosensitizers for the inactivation of microbial pathogens

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• 作者：Polo ; Laura ; Segalla ; Anna ; Bertoloni ; Giulio ; Jori ; Giulio ; Schaffner ; Kurt ; Reddi ; Elena
• 关键词：Photosensitization ; Microbial pathogens ; Photosterilization ; Photodynamic therapy
• 刊名：Journal of Photochemistry and Photobiology B: Biology
• 出版年：2000
• 出版时间：December, 2000
• 年：2000
• 卷：59
• 期：1-3
• 页码：152-158
• 全文大小：185 K

文摘

Porphycenes are electronic isomers of porphyrins which, when neutral, display no appreciable photosensitizing action towards Gram-negative bacteria. The covalent binding of oligomeric polylysine moieties, which are cationic at physiological pH values, endows porphycenes with a significant phototoxic activity against Gram-negative bacteria while retaining their photoefficiency against a variety of microbial pathogens, including Gram-positive bacteria, fungi and mycoplasmas. The effect of the polylysine moiety is dependent on both the polylysine concentration and the degree of oligomerization. A suitable interplay among the various parameters opens the possibility to obtain either a broad spectrum of antimicrobial activity or a selective action toward a specific pathogen while minimizing the damage to human fibroblasts.