Toxicological evaluation of Pterocaulon polystachyum extract: A medicinal plant with antifungal activity

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• 作者：Gabriela Gregory Regner ; Janaí ; na Gianesini ; Rafael Gomes Von Borowski ; Fabiana Silveira ; Juliane Garcia Semedo ; Alex ; re de Barros Falcã ; o Ferraz ; Elenir Wiill ; Gilsane Von Poser ; Mariâ ; n
• 关键词：Pterocaulon polystachyum ; Acute toxicity ; Subacute toxicity ; Biochemical assay ; Comet assay ; Micronucleus assay
• 刊名：Environmental Toxicology and Pharmacology
• 出版年：2011
• 出版时间：January 2011
• 年：2011
• 卷：31
• 期：1
• 页码：242-249
• 全文大小：255 K

文摘

Pterocaulon polystachyum DC is a native species to southern Brazil, Paraguay, Uruguay and northeastern Argentina. It is utilized to treat animal problems popularly diagnosed as “mycoses”. The antifungal and amebicidal activity of its hexane extract has been previously reported, although there are no studies confirming the safety of this plant for therapeutic purposes to date. Hence, this study investigates the toxic effects of a hexane extract of Pterocaulon polystachyum administered as acute and subacute oral treatments. After acute treatment the extract caused alterations in biochemical parameters, morphological alterations in tissues and was genotoxic, according to the comet assay; neither mortality nor visible signs of lethality were seen in mice. Similarly subacute treatment caused important differences in biochemical parameters and tissues, between control and treated groups. The results also revealed genotoxicity in kidney tissue, though no mutagenicity was detected by the micronucleus test. No animal died during the treatment period.