DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression

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• 作者：Irina V. Pronina^a ; ¹ ; Vitaly I. Loginov^a ; ¹ ; Alexey M. Burdennyy^a ; Marina V. Fridman^a ; Vera N. Senchenko^b ; Tatiana P. Kazubskaya^c ; Nikolay E. Kushlinskii^c ; Alexey A. Dmitriev^b ; Eleonora A. Braga^a ; ^{eleonora10_45@mail.ru}
• 关键词：miRNA ; microRNA ; mRNA ; messenger RNA ; cDNA ; coding DNA ; BC ; breast cancer ; NSCLC ; non-small cell lung cancer ; ld ; low-differentiated ; md ; moderate-differentiated ; hd ; high-differentiated ; qPCR ; quantitative PCR ; MSP ; methylation-specific PCR ; rs ; Spearman's correlation coefficient ; FDR ; false discovery rate ; KEGG ; Kyoto Encyclopedia of Genes and Genomes ; GO ; Gene Ontology
• 刊名：Gene
• 出版年：2017
• 出版时间：10 March 2017
• 年：2017
• 卷：604
• 期：Complete
• 页码：1-8
• 全文大小：678 K
• 卷排序：604

文摘

Hypermethylation of MIR-125b-1, -127, -132, -193a, and -34b was revealed in BC Hypomethylation of MIR-191 was shown in primary breast tumors MIR-124-1, 125b-1, 127, 132, 193a, 34b methylation correlated with down-regulation Levels of miR-127-5p, -124-3p, -375 and DAPK1, BCL2, RASSF1(A) correlated negatively Hypermethylation of MIR-127 and -125b-1 was associated with breast cancer progression