Genetic diversity in Ebola virus: Phylogenetic and in silico structural studies of Ebola viral proteins

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• 作者：Alba Grifoni¹ ; Alessandra Lo Presti² ; Marta Giovanetti² ; ³ ; Carla Montesano³ ; Massimo Amicosante¹ ; ⁴ ; Vittorio Colizzi³ ; Alessia Lai⁵ ; Gianguglielmo Zehender⁵ ; Eleonora Cella² ; ⁶ ; Silvia Angeletti⁷ ; Massimo Ciccozzi² ; ⁸ ; ^{ciccozzi@iss.it" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Ebola virus ; Proteins ; Evolutionary analysis
• 刊名：Asian Pacific Journal of Tropical Medicine
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：9
• 期：4
• 页码：337-343
• 全文大小：1410 K

文摘

To explore the genetic diversity and the modification of antibody response in the recent outbreak of Ebola Virus.

Methods

Sequences retrieved from public databases, the selective pressure analysis and the homology modeling based on the all protein (nucleoprotein, VP35, VP40, soluble glycoprotein, small soluble glycoprotein, VP30, VP24 and polymerase) were used.

Results

Structural proteins VP24, VP30, VP35 and VP40 showed relative conserved sequences making them suitable target candidates for antiviral treatment. On the contrary, nucleoprotein, polymerase and soluble glycoprotein have high mutation frequency.

Conclusions

Data from this study point out important aspects of Ebola virus sequence variability that for epitope and vaccine design should be considered for appropriate targeting of conserved protein regions.