Selective amotivation deficits following chronic psychosocial stress in mice
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- 作者：Alejandro Tsai Cabala ; b ; c ; 1 ; Horea-Ioan Ioanasa ; b ; d ; Erich Seifritza ; b ; e ; Bechara J. Saab ; PI Dra ; b ; e ; bechara.saab@uzh.ch" class="auth_mail" title="E-mail the corresponding author ; beshsaab@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CSD ; chronic social defeat ; MDD ; major depressive disorder ; EPM ; elevated plus maze ; NFT ; new frontier task
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：15 January 2017
- 年：2017
- 卷：317
- 期：Complete
- 页码：424-433
- 全文大小：2056 K
文摘
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We find psychosocial stress in mice affects amotivation non-uniformly.
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Our chronic social defeat manipulation blunts novelty-driven exploration.
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Fear-driven exploration is comparatively resistant to psychosocial stress.
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Anxiety and short-term memory are also unaffected by the CSD manipulation used here.
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Fostering exploration could be a novel treatment for depression.