Different words, same meaning: understanding the languages of the genome

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• 作者：Greg Elgar
• 刊名：Trends in Genetics
• 出版年：2006
• 出版时间：December 2006
• 年：2006
• 卷：22
• 期：12
• 页码：639-641
• 全文大小：344 K

文摘

There is undeniable value in using sequence comparison to identify putative regulatory sequences. However, a recent report has demonstrated that not all regulatory sequences are evolutionarily conserved. Cis-acting sequences around the RET gene, conserved in mammals but not in fish, are able to reproduce patterns of RET expression in zebrafish embryos. It is as yet unclear whether these sequences are ‘below the radar’ of current sequence alignment tools or whether their functional homology is not sequence based.