Improving wheat to remove coeliac epitopes but retain functionality

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• 作者：Peter R. Shewry^a ; ^b ; ^{peter.shewry@rothamsted.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Arthur S. Tatham^c
• 关键词：Wheat ; Coeliac disease ; Coeliac-safe ; Breeding
• 刊名：Journal of Cereal Science
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：67
• 期：Complete
• 页码：12-21
• 全文大小：610 K

文摘

<dl class="listitem" id="list_ulist0010"><dt class="label">•dt><dd>

d="p0010">Coeliac disease is of increasing concern as its incidence appears to be increasing.

dd><dt class="label">•dt><dd>

d="p0015">Over 30 amino acid sequences (coeliac epitopes) have been defined.

dd><dt class="label">•dt><dd>

d="p0020">Coeliac epitopes differ in their distribution between wheat gluten proteins.

dd><dt class="label">•dt><dd>

d="p0025">Transgenesis can be used to reduce coeliac-toxic proteins and coeliac epitopes.

dd><dt class="label">•dt><dd>

d="p0030">This can be exploited to develop &ldquo;coeliac-safe&rdquo; wheats.

dd>dl>