IgG anti-tTG responses in different autoimmune conditions differ in their epitope targets and subclass usage

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• 作者：Ross Comerford^a ; ^b ; ^c ; ^{comerfor@tcd.ie" class="auth_mail" title="E-mail the corresponding author} ; Jacinta Kelly^a ; Conleth Feighery^b ; ^c ; Greg Byrne^d
• 关键词：Tissue transglutaminase ; Coeliac disease ; Autoimmunity ; Autoantibodies ; Type 1 diabetes ; Granulomatosis with polyangiitis
• 刊名：Molecular Immunology
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：67
• 期：2
• 页码：369-376
• 全文大小：1024 K

文摘

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d="par0005">Coeliac disease IgG anti-tTG epitopes are shared with those of the coeliac disease IgA anti-tTG response.

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d="par0010">Epitopes recognised by coeliac disease IgG anti-tTG differ from those of IgG anti-tTG in other autoimmune conditions.

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d="par0015">IgG anti-tTG subclass usage in coeliac disease and Type 1 diabetes mellitus is predominantly IgG1.

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d="par0020">The IgG anti-tTG response was more frequently composed of IgG2&ndash;IgG4 antibodies in non-coeliac IgG anti-tTG positive individuals.

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