A CLCNKA polymorphism (rs10927887; p.Arg83Gly) previously linked to heart failure is associated with the estimated glomerular filtration rate in the RENASTUR cohort
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- 作者：Beatriz Tavira ; Juan G¨®mez ; Francisco Ortega ; Salvador Tranche ; Carmen D¨ªaz-Corte ; Francisco Alvarez ; Alberto Ortiz ; Fern ; o Santos ; Mar¨ªa D. S¨¢nchez-Ni?o ; Eliecer Coto
- 关键词：CLCNKA ; Ka renal chloride channel gene ; HSPB7 ; heat shock protein B7 gene ; SNPs ; single nucleotide polymorphisms ; CKD ; chronic kidney disease ; eGFR ; estimated glomerular filtration rate ; BMI ; body mass index ; MDRD ; Modification of Diet in Renal Disease ; R
- 刊名：Gene
- 出版年：2013
- 出版时间：25 September, 2013
- 年：2013
- 卷：527
- 期：2
- 页码：670-672
- 全文大小：154 K
文摘
A total of 569 individuals aged 55-85 and Caucasian were genotyped for SNP rs10927887 in the Ka renal chloride channel gene (CLCNKA). The following variables were significantly associated with an estimated glomerular filtration rate of (eGFR) < 60 ml/min./1.73 m2: age, type 2 diabetes, total cholesterol, LDL-cholesterol, and the CLCNKA GG genotype (p = 0.03; OR = 1.65, 95 % CI = 1.04-2.62). This novel finding could partly explain the reported greater risk of heart failure linked to the CLCNKA SNP, but requires confirmation on other populations.